感觉神经释放的CGRP通过抑制TILs来增加HNSCC中的瘤生长
Laurel B Darragh1, Alexander Nguyen2, Tiffany T Pham3
1Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA; Department of Immunology and Microbiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
Med (New York, N.Y.)
|February 29, 2024
概括
头癌中的感觉神经抑制了抗瘤T细胞. 阻断神经功能或与素基因相关的 (CGRP) 可能会改善免疫反应和HNSCC的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 脑周神经侵袭和头平细胞癌 (HNSCC) 中的神经密度增加与患者的不良结果相关.
- 瘤微环境 (TME) 神经对适应性免疫和瘤进展的影响仍然不完全理解.
研究的目的:
- 研究HNSCC瘤微环境中的感觉神经调节适应性免疫系统并影响瘤生长的机制.
主要方法:
- 人类HNSCC瘤组织的RNA测序.
- 来自HNSCC患者的人类神经的蛋白质组分析.
- 使用了与HPV无关的HNSCC的Syngeneic Orthotopic小鼠模型.
主要成果:
- 发现素基因相关 (CGRP) 在体外直接抑制CD8T细胞活性.
- 通过手术,药物或遗传手段阻断感官神经活动,在体内增强了CD8和CD4T细胞活性.
结论:
- 感觉神经通过在TME中抑制Th1 CD4和激活的CD8 T细胞来促进HNSCC的进展.
- 准感觉神经功能或CGRP活动是一个潜在的治疗策略,可以改善HNSCC的抗瘤免疫力和患者的治疗结果.
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