通过口服Ox66的氧化在呼吸困难的两次撞击动物模型中
Bjorn K Song1, Danuel A Carr1, Erica D Bruce2
1Song Biotechnologies LLC, Baltimore, MD, USA.
Artificial cells, nanomedicine, and biotechnology
|February 29, 2024
概括
在急性呼吸困扰综合征 (ARDS) 的老鼠模型中,可以摄入的氧气Ox66TM改善了间歇性氧化和抑制了炎症. 这表明Ox66TM可能是肺功能障碍和缺氧的可行治疗方法.
科学领域:
- 生理学 生理学 生理学
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 急性呼吸系统应急综合征 (ARDS) 会导致危及生命的低氧化症,并可能导致多器官衰竭.
- 目前的治疗方法,如通风和高氧化,可能无法完全解决毛细血管床中未被检测到的缺氧.
- Ox66TM是一种创新的可摄入,固态氧,旨在补充缺氧.
研究的目的:
- 在ARDS的老鼠模型中评估Ox66TM在改善氧化和心血管功能的有效性.
- 为了比较Ox66TM与补充启发氧气 (40%FiO2) 和盐水对照在治疗ARDS诱导的缺氧.
- 评估Ox66TM对与ARDS相关的炎症反应的影响.
主要方法:
- 在24只麻醉大鼠中,使用脂聚糖化物 (LPS) 和降低潮体积诱导了一种双击ARDS模型.
- 动物被随机分配给接受Ox66TM,正常盐水 (NS) 或40%的FiO2.2.
- 测量了心血管功能,血液氧度/化学,以及脊柱肌中间歇性氧化 (PISFO2).
主要成果:
- 与基线相比,ARDS在所有组中显著降低了平均动脉压 (MAP) 和PISFO2.
- 与NS相比,Ox66TM和40%FiO2治疗改善了PISFO2,保持了较高的水平.
- 无论是Ox66TM还是40%的FiO2治疗都抑制了对LPS的炎症反应.
结论:
- 在ARDS的老鼠模型中,Ox66TM有效地改善了间歇性氧化.
- 可摄入氧气补充剂在缓解缺氧和抑制肺功能障碍期间的炎症方面表现出潜在的潜力.
- Ox66TM代表了一种有前途的治疗选择,用于涉及低氧化和ARDS的疾病.
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