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在单方面伯明翰部重新表面化后,金属水平和膜过率
Charles A Engh1, Vinay Bhal2, Robert H Hopper3
1Anderson Orthopedic Clinic & Inova Mount Vernon Joint Replacement Center, Alexandria, Virginia, USA.
The bone & joint journal
|February 29, 2024
概括
伯明翰部表面修复 (BHR) 增加了和水平,但在十年内不会对功能产生不利影响. 手术前较低的功能可能与手术后更高的含量增加有关.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学 生物材料科学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 金属对金属的部植入物,如伯明翰部复面 (BHR),可以将金属离子释放到循环中.
- 评估这些离子对功能的长期影响对于患者的安全至关重要.
研究的目的:
- 调查BHR后血液金属离子水平在手术前功能和手术后变化之间的关联.
- 为了确定长时间暴露于高 (Co) 和 (Cr) 水平是否会在十年内影响功能.
主要方法:
- 一项前性多中心研究,涉及117名单边BHR植入物患者.
- 分析了全血样本的Co和Cr水平,并预计了手术前和手术后1,4,5年和10年的球过率 (eGFR).
主要成果:
- 术后的Co和Cr水平在一年内显著增加,中位数分别上升了9.7倍和2.5倍.
- 较低的手术前eGFR与一年后的C0水平的更大增加有关,但Cr.
- 金属离子水平在十年内保持稳定,并且在十年的Co/Cr水平和eGFR变化之间没有发现显著的关系.
结论:
- 虽然术前较低的功能可能与更高的含量增加有关,但BHR植入物在术后的前十年没有对功能产生不利影响.
- 对BHR患者的功能进行长期监测是有必要的,尽管目前的数据表明,金属离子暴露没有显著的不良影响.
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