丸激素治疗和心血管疾病的风险在老年人中,阴茎下垂的男性
Srikanth Krishnan1, Jairo Aldana-Bitar1, Ilana Golub2
1The Lundquist Institute at Harbor-UCLA, 1124 W Carson St, Torrance, CA 90502.
Progress in cardiovascular diseases
|February 29, 2024
概括
激素治疗 (TT) 显示了心脏代谢的好处,没有短期的心血管风险,但长期的影响需要进一步研究. 对TT的临床决策应优先考虑个性化护理和知情的患者讨论.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 关于丸激素治疗 (TT) 的心血管 (CV) 安全性存在不同的全球指导方针.
- 低内源性丸激素在观察性研究中可变地与心血管疾病 (CVD) 风险增加有关.
研究的目的:
- 批判性地审查关于TT在衰老,肥胖和内源性激素环境中的CV影响的长期研究.
- 支持关于启动丸激素治疗的知情临床决策.
主要方法:
- 叙述性综述综合了观察性研究和随机对照试验 (RCT) 的发现.
- 关键试验的批判性评估,如TRAVERSE和TTrials心血管子研究.
- 分析考虑了诸如衰老,肥胖和内生性激素等因素.
主要成果:
- 风险试验表明,TT提供心脏代谢益处,而不会增加短期心血管风险.
- 在TRAVERSE试验中,没有发现主要心脏不良事件 (MACE) 的增加,但有局限性 (低水平,高停药,短时间的随访).
- TTrials子研究表明非化斑块的增加,突出了长期研究的必要性.
结论:
- 关于丸激素治疗的长期心血管效应的证据缺口仍然存在,特别是在现有心血管疾病的老年男性中.
- 通过外源性给药来维持生理水平的CV影响需要进一步探索.
- 临床实践应强调个性化护理,并全面讨论潜在的CV风险和TT的好处.
关键词:
衰老,肥胖和丸激素的作用动脉样硬化和丸激素的发生心血管疾病是什么心血管疾病冠状动脉中的.冠状动脉疾病是一种冠状动脉疾病.催产素缺陷症是什么 催产素缺陷症没有化的斑块.在TRAVERSE的审判中,丸激素治疗疗法更多相关视频
07:25A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.1K
07:40Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
Published on: October 10, 2019
7.3K
相关概念视频
01:26Testosterone: Functions and Regulation
648
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
648
01:20Disorders of the Male Reproductive System
414
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
414
01:20Exercise and Cardiovascular Response
808
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
808
01:23Antihypertensive Drugs: Vasodilators
519
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
519
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
163
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
163
01:27Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30