扩大杏仁体动态的急性和慢性酒精调节
Alison V Roland1, Tzu-Hao Harry Chao2, Olivia J Hon1
1Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Alcohol (Fayetteville, N.Y.)
|February 29, 2024
概括
中枢桃体 (CeA) 和末端 (BNST) 的床核在饮酒期间显示神经元活动发生变化. 慢性酒精改变了这些大脑区域的活动动态,特别是在dynorphin神经元中.
科学领域:
- 神经科学是一个神经科学.
- 酒精研究 酒精研究
- 行为科学 行为科学
背景情况:
- 中枢桃体 (CeA) 和末的床核 (BNST) 是扩展桃体中关键的大脑区域,参与酒精消费.
- 之前的研究表明,这些区域信号酒精奖励和介导负面强化,但他们的实时神经元活动动态在饮酒时尚不清楚.
研究的目的:
- 研究饮酒期间在CeA和BNST中神经元激活的时间动态.
- 检查慢性酒精暴露如何改变这些地区的神经元活动和网络连贯性.
主要方法:
- 使用GCaMP6s传感器的纤维光度测量用于测量CeA和BNST中的泛神经元和dynorphin特定的神经元活动.
- 在急性饮酒期间和慢性三周饮酒后评估神经元活动.
主要成果:
- 在饮用酒精和其他品味剂时,CeA和BNST都表现出增加的泛神经活动,随着重复暴露,反应会减少,这表明新奇性调节.
- 在这两个区域的丁诺芬神经元都显示了与消费相关的量增加,在长期饮酒后保持不变.
- 慢性酒精暴露改变了泛神经活动和BNST-CeA连贯性,以性别特定的方式.
结论:
- 在饮酒行为期间,CeA和BNST,包括特定的迪诺芬神经元,都在积极参与饮酒行为.
- 这些区域的神经元活动动态受到刺激新性和慢性酒精暴露的影响,观察到性别特异性的改变.
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