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关于冠状病毒主蛋白酶的无活化

Hong Ha Nguyen1, Jim Tufts1, David D L Minh1

  • 1Department of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States.

Journal of chemical information and modeling
|February 29, 2024
PubMed
概括

了解SARS-CoV-2主要蛋白酶 (MPro) 的非活性构造是药物设计的关键. 这项研究揭示了独特的非活性状态,并确定了关键残留物,挑战了关于酶活性的现有假设.

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