患有T4b或阻塞性结肠癌的患者的新辅助化疗:单中心回顾性队列研究
Yuho Ebata1, Ryota Nakanishi2, Yasushi Tanaka1
1Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Anticancer research
|February 29, 2024
概括
新辅助化疗 (NAC) 是可行的局部晚期结肠癌 (LACC) 与T4b或阻塞性T4a阶段. 这种治疗选择显示出有前途的结果,包括R0切除和降级,并具有可控的副作用.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 新辅助化疗 (NAC) 在结肠癌中的作用尚未得到充分证实.
- 局部晚期结肠癌 (LACC) 存在独特的治疗挑战.
研究的目的:
- 评估局部晚期T4b或阻塞性T4a结肠癌患者中NAC的结果.
- 评估NAC对LACC的可行性和安全性.
主要方法:
- 在手术前接受NAC的11名LACC患者的回顾性审查 (2010-2022).
- 分析患者特征,手术结果,瘤特征和预后.
- 作为一个双重疗程,NAC被管理了三个月的中位数.
主要成果:
- 所有11名患者都实现了R0切除;8人显示瘤下降阶段.
- 在NAC期间没有报告≥3级不良事件.
- 四名患者出现了复发 (两名肝脏,两名局部),其中三名接受了切除.
结论:
- 新辅助化疗 (NAC) 是T4b或阻塞性T4a结肠癌的可行的治疗选择.
- NAC可能会改善手术结果,并允许LACC中的瘤衰退.
- 需要进行更大规模的研究来证实NAC在LACC中的疗效.
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