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MYC通过促进pRB1降解来诱导CDK4/6抑制剂的耐药性

Jian Ma1,2,3, Lei Li1,2,3, Bohan Ma1,2,3

  • 1Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Nature communications
|February 29, 2024
PubMed
概括

在癌症中,MYC放大会导致对CDK4/6抑制剂 (CDK4/6i) 的抗性. 一种新的化合物,A80.2HCl,降解MYC,恢复对CDK4/6i的敏感性,并减少瘤生长.

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