病毒对调节微生物甲代谢的潜力因息地而异
Zhi-Ping Zhong1,2,3, Jingjie Du2,4, Stephan Köstlbacher5,6,7
1Byrd Polar and Climate Research Center, Ohio State University, Columbus, OH, USA.
Nature communications
|February 29, 2024
概括
病毒通过编码辅助代谢基因 (AMG) 在甲代谢 (MM) 中发挥作用. 富含甲环境中的病毒性AMG不同,这表明息地特定的病毒在宿主新陈代谢中的作用.
科学领域:
- 环境微生物学环境微生物学
- 病毒学 病毒学
- 生物地质化学循环过程
背景情况:
- 甲是一种强大的温室气体,其循环主要由微生物驱动.
- 病毒在微生物甲代谢 (MM) 中的作用仍然在很大程度上未被探索.
- 辅助代谢基因 (AMG) 是修改宿主代谢的病毒基因.
研究的目的:
- 通过分析辅助代谢基因 (AMG) 来研究病毒对甲代谢 (MM) 的贡献.
- 在多种息地中识别MM相关的新型AMG及其病毒宿主.
- 探索富含甲沉积物的病毒社区组成和代谢潜力.
主要方法:
- 分析了来自各种宿主相关和环境息地的982个公共元基因组.
- 已知甲代谢 (MM) 辅助代谢基因 (AMG) 的识别和扩展.
- 从富含甲的弗拉纳湖沉积物中生成和分析元基因组.
主要成果:
- 已知MM相关的AMG的目录从3个扩展到24个,其中7个仅限于MM路径.
- 鉴定出911个编码这些AMG的病毒结合体,感染了14个 prokaryotic 类,主要在病毒中.
- 弗拉纳湖的病毒群体显示出对宿主代谢调节的潜力,但缺乏直接的MM AMG.
结论:
- 病毒辅助代谢基因 (AMG) 参与甲代谢 (MM),特别是在皮环境中.
- 病毒AMG在调节宿主代谢中的患病率和功能在不同息地之间有很大差异.
- 像甲循环这样的生物地球化学过程中的病毒作用是复杂的,不仅仅是通过息地特征可预测的.
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