青少年对社会包容/排斥的感知和对过去自杀企图的反应抑制:基于任务的多领域fMRI研究
Anthony J Gifuni1,2,3, Fabricio Pereira4,5,6, M Mallar Chakravarty2
1McGill Group for Suicide Studies, Douglas Mental Health University Institute, Montréal, Canada.
Molecular psychiatry
|February 29, 2024
概括
青少年的自杀行为与改变社会处理和反应抑制中的大脑活动有关. 神经成像可以通过揭示这些神经差异来帮助识别有风险的年轻人.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 自杀行为在青春期增加,可能与社会过敏和认知控制缺陷有关.
- 功能神经成像提供了一种潜在的方法,可以超越传统的临床评估来识别有风险的年轻人.
研究的目的:
- 在社会和认知任务期间调查有或没有自杀尝试 (SA) 史的青少年的神经差异.
- 探索多域功能神经成像在识别与青少年自杀行为相关的神经生物学标志物的实用性.
主要方法:
- 三组青少年 (N=96) 在社会排斥 (网络球游戏) 和响应抑制 (Go-NoGo) 任务期间接受了3T-MRI.
- 神经激活 (BOLD信号) 用ANCOVA对整个大脑进行了分析:NoGo与Go对比,社会包容与控制,社会排斥与控制.
主要成果:
- 与对照人群相比,SA的青少年在社会包容期间显示左侧胰岛激活减少.
- 与患者对照组相比,SA组在社会排斥期间在右中前额回环和在响应抑制期间在双边前中心回环中表现出更高的活动.
- 行为和自我报告措施没有区分这些群体.
结论:
- 青少年的自杀行为与处理社会线索和执行响应抑制的明显神经改变有关.
- 神经成像可以作为一种有价值的工具,以了解青少年自杀行为的出现和进展,保证进一步的前性研究.
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