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在拔牙后,SDF-1参与了正牙牙移动

Duangtawan Rintanalert^1,2, Yuji Ishida³, Albert Chun-Shuo Huang¹

¹Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8510, Japan.

Scientific reports

|February 29, 2024

概括

阻断肌体细胞衍生因子1 (SDF-1) /化学因子受体4型 (CXCR4) 轴与抗体减少牙运动速度和炎症. 这种有针对性的方法为控制正统牙移动 (OTM) 和相关的骨变化提供了潜力.

科学领域:

生物医学科学生物医学科学
矯正牙科矯正牙科是一種矯正牙科.
牙周病学牙周病学

背景情况:

树突细胞衍生因子1 (SDF-1) /化学因子受体4型 (CXCR4) 轴在正统牙运动 (OTM) 期间对膜骨代谢至关重要.
了解它的作用是调节OTM速度和牙周变化的关键,特别是在牙拔牙后.

研究的目的:

研究SDF-1/CXCR4轴对OTM中的区域加速现象 (RAP) 的影响.
为了评估阻断这个轴对牙周变化的影响,在老鼠模型中取相邻的牙后.

主要方法:

在老鼠身上,使用封闭式卷轴弹,进行了上第一个头的提取和第二个头的 mesial OTM.
酸盐缓冲盐水注射,IgG同型控制或抗SDF-1抗体被局部使用.
对OTM距离,骨质细胞活性和炎症标志物的分析在1,3和7天进行.

主要成果:

提取后SDF-1表达显著增加,而这种表达被抗SDF-1抗体阻断.
抗SDF-1治疗显著减少了M2 OTM距离和骨质细胞数量在第3天.
在实验组中,局部炎症标志物也减少了.

结论:

对抗SDF-1中和抗体的连续局部注射有效地降低了OTM速度.
这种干预也降低了OTM中骨质细胞积累和局部炎症反应,与提取诱导的RAP.
准SDF-1/CXCR4轴为管理OTM提供了一个可行的策略.

关键词:

中和抗体的抗体 ортодонтик牙运动 (OTM) 的牙运动.区域加速现象 (RAP) 是一个区域加速现象.流体细胞衍生因子1 (SDF-1)拔牙是指拔牙的方式.

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