为乳腺癌相关的淋巴结胀制定一个核心结局:Delphi研究
David Doubblestein1, Linda Koehler2, Elizabeth Anderson3
1Department of Physical Therapy, A.T. Still University, Mesa, AZ, USA. daviddoubblestein@atsu.edu.
Breast cancer research and treatment
|February 29, 2024
概括
开发了一个核心结果集 (COS),以标准化乳腺癌相关淋巴 (BCRL) 在幸存者的测量. 这种COS确保了医疗保健专业人员对疾病负担和干预有效性的一致评估.
科学领域:
- 在瘤学瘤学.
- 康复医学 康复医学 康复医学
- 淋巴 edem 研究 研究 淋巴 edem 研究
背景情况:
- 与乳腺癌相关的淋巴 (BCRL) 对幸存者来说是一个重大负担.
- 标准化结果测量对于评估BCRL和干预疗效至关重要.
- 需要一个核心成果集 (COS) 来解决临床和研究环境中的时间限制.
研究的目的:
- 建立一个用于测量乳腺癌幸存者的BCRL负担的COS.
- 确定评估BCRL和指导干预策略的结果领域 (OD).
- 在BCRL管理和研究中促进标准化和一致的报告.
主要方法:
- 用德尔菲方法与BCRL专家组成的多学科小组合作.
- 进行了两轮在线调查,以收集专家的共识.
- 使用70%80%的共识值来确定将OD纳入COS.
主要成果:
- 为了评估BCRL,开发了一个12个域的COS.
- 时间受限设置的关键OD包括体积,组织一致性,疼痛,患者报告的功能和生活质量以及上肢活动.
- 额外的OD (关节功能,灵活性,力量,感觉,移动性,平衡,疲劳) 被确定为不受约束的设置.
结论:
- 开发的COS全面捕捉了BCRL负担.
- 实施这种COS可以减轻选择性报告和临床实践中的不一致性.
- 通过COS进行标准化结果测量将改善BCRL的研究和跨学科的护理.
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