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Updated: Jul 5, 2026

Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications
06:34

Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications

Published on: March 8, 2024

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功能性肠道单层来自从人类iPS细胞中提取的有机物,用于药物发现研究

Tatsuya Inui1,2, Yusei Uraya3, Jumpei Yokota1,2

  • 1Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Stem cell research & therapy
|February 29, 2024
PubMed
概括

有机体技术使得从诱导的多能干细胞中产生可扩展的,高质量的人类肠道有机体 (ELC-org) 和单层 (ELC-org-mono). 这些模型增强了药物吸收和新陈代谢研究,比原始的肠球样细胞提供了更好的功能和方便.

关键词:
毒品运输商 毒品运输商药物代谢酶的药物代谢酶.肠道有机物 肠道有机物小肠 小肠小肠的小肠.在iPS的手机上,iPS是iPS的细胞.

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相关概念视频

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...