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相关概念视频

Termination of Translation01:44

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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A reference frame accelerating or decelerating relative to an inertial frame is a non-inertial frame. To help understand this, consider what taking off in an airplane, turning a corner in a car, riding a merry-go-round, and the circular motion of a tropical cyclone all have in common. All these systems are accelerating, decelerating, or rotating relative to the Earth; hence, they all are non-inertial frames. All these systems exhibit inertial forces, which merely seem to arise from motion,...
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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
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翻译:最后的边界?

Terry Kenakin1

  • 1Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina, USA.

British journal of pharmacology
|March 1, 2024
PubMed
概括

偏差的G蛋白合受体 (GPCR) 信号在药物发现中很常见. 将体外偏差转化为体外效应仍然是预测治疗价值的挑战.

科学领域:

  • 药理学 药理学是指药理学的学科.
  • 生物化学 生物化学
  • 药物发现 药物发现 药物发现

背景情况:

  • 偏差信号传递是G蛋白合受体 (GPCR) 全质调制的固有属性.
  • 这种现象预计来自自然和合成激动剂,并且经常在激动剂发现项目中观察到.
  • 偏差信号可能是潜在候选药物的有益或有害特征.

研究的目的:

  • 审查将体外检测到的偏差GPCR信号转化为体内系统的挑战.
  • 讨论由于翻译失败而导致的偏差信号的治疗价值预测的困难.
  • 探索新的策略,以改善治疗利用偏差信号的翻译.

主要方法:

  • 关于GPCR信号传递和偏见激进主义的现有文献的审查.
  • 对将体外发现转化为体内药理结果的复杂性进行分析.
  • 讨论当前和新兴的方法来评估和预测在生物体中偏差配体的疗效.

主要成果:

  • 偏差信号传递是GPCRs的普遍特征,源于它们的全osteric功能.
  • 在体外发现的偏差信号转化为体内疗效是有问题的,并且阻碍了治疗预测.
  • 目前的方法在准确预测体外观察到的偏差信号的体外后果方面面临挑战.
关键词:
有偏见的信号传输.发现药物的发现.接收器的激发性反应.

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结论:

  • 偏差信号是GPCR药理学的一个组成部分,必须在药物开发中考虑.
  • 克服体外到体内翻译差距对于利用偏向GPCR激动剂的治疗潜力至关重要.
  • 需要对新型预测模型和实验方法进行进一步的研究,以有效地利用偏差信号机制.