为了更好地理解形大脑是如何发展的
Mikaela Barresi1,2, Ryan Alexander Hickmott1,2, Abdulhameed Bosakhar1
1School of Health and Biomedical Sciences, RMIT University, Plenty Road, Bundoora, VIC 3083, Australia.
Cerebral cortex (New York, N.Y. : 1991)
|March 1, 2024
概括
大脑皮层的进化涉及折叠 (回脑) 在一些物种中,增强认知能力. 最近的发现强调了外腹腔下部区域和基底辐射质细胞对于这个复杂的发育过程至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 进化生物学 进化生物学
背景情况:
- 大脑皮层的大小和形状在进化过程中有所不同,有光滑的 (lissencephalic) 和折叠的 (gyrencephalic) 形状.
- 灵长类动物中常见的脑皮层提供了增加的表面积,厚度和神经元密度,与更高的认知功能相关.
- 驱动化与脑病的机制,尽管有共同的神经发育路径,仍然是一个长期存在的研究问题.
研究的目的:
- 审查大脑扩张和皮质折叠 (化) 的关键方面.
- 探索旋转的理论是如何随着新的科学知识而发展的.
- 综合当前对皮层折叠的驱动因素的理解.
主要方法:
- 审查关于大脑皮层进化和发展的现有文献.
- 对转录数据和基因操纵模型的分析.
- 检查影响化的生物机械,遗传和细胞过程.
主要成果:
- 确定外腹腔下部区域和基底放射性质细胞对于皮质扩张和折叠至关重要.
- 转录分析和基因操纵揭示了化的关键细胞和遗传驱动因素.
- 生物机械,遗传和细胞因子对变的确切贡献仍在调查中.
结论:
- 外腹腔下区域和基底辐射质细胞对于化大脑皮层的发展是不可或缺的.
- 了解遗传,细胞和生物力学因素的相互作用是完全解释化的关键.
- 本综述综合了当前的知识,突出了化理论的动态演变.
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