术前控制营养状况作为一个最佳的预后营养指数来预测结直肠癌的结果
Li-Xiang Liu1, Hao Wang2, Bo Gao3
1Department of General Surgery, Nanjing Drum Tower Hospital, Nanjing Drum Tower Hospital Clinical College, Nanjing Medical University, Nanjing 210008, Jiangsu Province, China.
World journal of gastrointestinal oncology
|March 1, 2024
概括
控制营养状况 (CONUT) 评分有效预测结直肠癌手术后的生存率. 较高的CONUT分数表明结果更差,在预测患者预后方面表现优于其他营养指数.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 营养科学 营养科学
背景情况:
- 营养状况显著影响癌症预后.
- 控制营养状况 (CONUT) 评分是营养状况的验证指标.
- 术前营养评估对于预测癌症患者的结果至关重要.
研究的目的:
- 评估CONUT得分能够预测经过激进手术的结直肠癌患者的生存率.
- 将CONUT得分的预测性能与其他已建立的预测指数进行比较.
主要方法:
- 对217名结肠直肠癌患者的回顾性分析.
- 基于血清白蛋白,淋巴细胞总数和总胆固醇的CONUT得分的计算.
- 卡普兰-梅尔曲线和考克斯回归分析,以评估生存结果.
主要成果:
- 具有高CONUT分数的患者的整体存活率 (OS) 和无复发存活率 (RFS) 显著降低.
- 与修改后的格拉斯哥预后得分,预后营养指数和中性粒细胞与淋巴细胞的比率相比,CONUT得分显示出更好的预测性能.
- 与TNM分期结合的CONUT得分显示了对3年OS和RFS的骨肌肉质量指数 (SMI) +TNM阶段的可比预测能力.
结论:
- CONUT评分是一个有价值的营养指标,用于预测术后结直肠癌患者的长期结果.
- CONUT评分对其他指数的预测优势凸显了其临床实用性.
- 在CONUT得分和骨肌肉质量之间存在潜在的相关性,这可能有助于其预后价值.
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