多基因分数澄清了心理健康和性别多样性之间的关系
Taylor R Thomas1, Ashton J Tener1, Amy M Pearlman2
1Department of Psychiatry, University of Iowa, Iowa City, Iowa.
Biological psychiatry global open science
|March 1, 2024
概括
性别多样化的个人表现出更高的心理健康风险,但遗传联系是复杂的. 对认知表现的多基因分数,而不仅仅是心理健康,与性别多样性有关,这表明细微的遗传影响.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 性别研究是性别研究.
背景情况:
- 性别多样的人面临着更高的心理健康挑战.
- 导致这种差异的基因和环境因素尚不清楚.
研究的目的:
- 调查多基因分数 (PGS) 与性别多样性和心理健康措施之间的关联.
- 探索潜在的共同遗传因素,影响性别认同和心理健康结果.
主要方法:
- 从SPARK队列中使用了两个大样本 (N=639和N=5165).
- 使用性别自我报告 (GSR) 和分类措施评估性别多样性.
- 检查了16个PGS (包括神经精神病,认知和行为特征) 和心理健康/性别多样性措施之间的关联.
主要成果:
- 神经精神病学PGS与心理健康症状 (例如,ADHD,抑郁症,神经病症) 有关.
- 性别多样性的测量显示了与认知表现PGS的显著关联,而不是神经精神病学PGS.
- 在第二项研究中的复制证实了认知表现PGS和性别认同 (变性人和非二进制个体) 之间的关联.
结论:
- 性别多样性在现象上与心理健康问题有关.
- 性别多样性的最强烈的遗传关联与认知表现有关,而不仅仅是神经精神病学因素.
- 这些发现表明,性别多样性存在复杂的遗传基础,与直接的精神病风险因素不同.
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