来自Agaricus bisporus产品的β-葡萄糖驱动训练的免疫力
Sarah Case1, Tara O'Brien1, Anna E Ledwith1
1School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.
Frontiers in nutrition
|March 1, 2024
概括
中的β-葡萄糖可以训练先天性免疫细胞,增强对Toll-like受体2刺激的反应. 这表明食用可能提供了一种通过训练免疫力来增强免疫系统的新方法.
科学领域:
- 免疫学 免疫学 免疫学
- 菌类学 菌类学是指菌类学.
- 生物化学 生物化学
背景情况:
- 宏观真菌,包括食用,具有抗菌和免疫调节的特性.
- 是β-葡萄糖的来源,聚糖类已知可以诱导训练免疫力.
- 衍生的β-葡萄糖诱导训练免疫力的能力尚不清楚.
研究的目的:
- 为了研究白色按 (Agaricus bisporus) 的β-葡萄糖能够诱导先天免疫细胞的训练免疫力.
- 探索粉和富含β-葡萄糖制剂对免疫细胞反应的影响.
- 评估消费对髓状细胞功能和造血原生细胞的体内影响.
主要方法:
- 鼠标的巨被预先用全粉 (WMP) 处理,并用托尔类受体 (TLR) 连接体刺激.
- 在WMP中应用了β-葡萄糖丰富策略 (体外消化,化学分化).
- 人体单细胞和体内小鼠模型 (WMP口腔测量) 用于评估免疫训练和造血变化.
主要成果:
- 治疗前WMP增强了对TLR2刺激的巨细胞反应,其影响与β-葡萄糖含量相关.
- 丰富的WMP制剂保留并提高了训练后的反应.
- 在体内,WMP和消化的WMP都训练了人体单细胞,并改变了髓状原生细胞群体,增强了成熟的巨细胞反应.
结论:
- 来自常见巨的β-葡萄糖可以有效地训练先天性免疫细胞.
- 来自的β-葡萄糖为开发用于教育先天免疫系统的新策略提供了有希望的途径.
- 可食用是饮食干预措施的潜在来源,以增强免疫准备.
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