持久性严重疾病和COVID-19患者的长期结果:一个多中心的回顾性队列研究
Ryan Ruiyang Ling1,2, William Bonavia3,4, Mallikarjuna Ponnapa Reddy4,5,6
1Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
在COVID-19患者中,持久性严重疾病 (PerCI) 与更糟糕的短期和长期结果有关. 在ICU治疗10天后,死亡风险趋于平稳,这表明PerCI会影响预后.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 持久性危急疾病 (PerCI) 是一种病情,在ICU过程中,而不是初始诊断,预测死亡率.
- 相当数量的ICU患者患有PerCI,因此需要对其特征和结果进行进一步调查.
研究的目的:
- 在COVID-19患者中描述PerCI.
- 分析患有PerCI的COVID-19患者的短期和长期结果.
主要方法:
- 多中心回顾性队列研究涉及114名澳大利亚ICU从2020年1月到2022年3月.
- 包括16岁以上的COVID-19患者和记录的ICU住院.
- 定义PerCI为在ICU停留时间≥10天,并使用Cox比例危险模型比较生存期长达2年.
主要成果:
- 在4961名患者中,有17.8%患有PerCI,ICU死亡率明显高 (23.4%对6.5%).
- 患有PerCI的患者表现出较低的2年生存率 (70.9%vs. 86.1%) 和增加的死亡风险 (aHR: 1.734).
- 在ICU10天之前,死亡风险不一致,但此后趋于平稳.
结论:
- 在COVID-19患者的PerCI与较差的短期和长期结果有关.
- 与PerCI相关的死亡风险在ICU入院的最初10天后稳定.
- 需要进一步的研究来确定PerCI的预测因子,以改善长期结果预测.
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