视神经外直径及其与儿科脑疟疾中脑胀的关联:一项回顾性研究
Madiha Q Raees1,2, Montfort Benard Gushu2, Terrie E Taylor2,3
1Division of Critical Care, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Frontiers in pediatrics
|March 1, 2024
概括
视神经外直径 (ONSD) 与大脑胀或儿科脑疟疾 (CM) 的结果没有可靠的相关性. 这表明ONSD不是评估CM患者疾病严重程度的合适工具.
科学领域:
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 儿童脑疟疾 (CM) 死亡率与大脑胀有关,但在低收入和中等收入国家 (LMICs) 中,MRI往往无法使用.
- 视神经外直径 (ONSD) 测量是一种低成本的方法来检测增加的内压力,与侵入性开口压力 (OP) 监测不同.
研究的目的:
- 评估增加的ONSD是否与儿童CM的MRI上脑部胀相关.
- 确定增加的ONSD是否与增加的OP和/或儿科CM中神经学结果不佳相关.
主要方法:
- 在马拉维 (2013-2022年) 对207名患有CM的儿童 (0-12岁) 的回顾性图表审查.
- 通过基于MRI的脑体积得分 (BVS) 评估的大脑胀;通过超声波测量ONSD.
- 使用斯皮尔曼等级相关性进行相关性分析.
主要成果:
- 在BVS和ONSD之间发现了微弱的正相关性 (r=0.14,p=0.05).
- 在86%的患者中观察到升高的ONSD;12%的患者增加了OP.
- 中位数ONSD根据放电结果或BVS (p>0.10) 并没有显著差异.
结论:
- 测量ONSD不是一个可靠的指标大脑胀,神经结果,或OP在儿科CM.
- 需要进一步的研究,以找到替代方法来早期识别高风险的CM患者.
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