长期COVID:神经表现 - - 一个更新的叙事审查
José Wagner Leonel1, Gabriella Cunha Vieira Ciurleo1, Alissa Moura Formiga1
1Universidade Federal do Ceará, Fortaleza CE, Brazil.
Dementia & neuropsychologia
|March 1, 2024
概括
在长期COVID中,SARS-CoV-2感染可能会导致神经问题,如认知和睡眠问题. 本综述探讨了这种普遍的疾病的流行症状,病理生理学和潜在的生物标志物.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在急性和长期COVID阶段,SARS-CoV-2感染经常导致神经症状.
- 神经学表现包括认知障碍,睡眠障碍,嗅觉功能障碍,精神问题和头痛.
- 这些症状不成比例地影响年轻人和女性,无论疾病的初始严重程度如何.
研究的目的:
- 对长期COVID中普遍存在的神经症状的当前知识进行审查.
- 讨论这些神经表现的病理生理学.
- 为了确定长期COVID神经症状的潜在生物标志物.
主要方法:
- 关于SARS-CoV-2和神经症状的研究文献综述.
- 报告认知,睡眠,嗅觉,精神和头痛障碍的分析.
- 检查拟议的病理生理机制和生物标志物.
主要成果:
- 长期COVID中神经症状非常普遍,导致显著的发病率.
- 经济负担很大,估计医疗保健成本约为3.7万亿美元.
- 病理生理学涉及潜在的神经炎症,病毒持久性和自身免疫反应.
结论:
- 长期COVID的神经症状代表着一个重大的公共卫生挑战.
- 了解病理生理学对于开发向治疗至关重要.
- 生物标志物的识别对于诊断和管理至关重要.
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