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Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
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高效的半导体模块可以为非压缩性出血提供可控的平行微通道.

Fengbo Yang1,2, Xiaoli Jia1,2, Chao Hua1,3

  • 1Engineering Research Center of the Ministry of Education for Wound Repair Technology, Jiangnan University, Affiliated Hospital of Jiangnan University, Wuxi, 214000, China.

Bioactive materials
|March 1, 2024
PubMed
概括

研究人员开发了一种微型热电半导体模块,以创建梯度和并行通道的水凝. 这些新型水凝表现出极好的液体吸收和血液静止能力,用于紧急伤口管理.

关键词:
发生出血 发生出血冰的模板 冰模板 冰的模板平行微通道平行微通道.热电半导体是一种热电半导体.

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科学领域:

  • 生物材料工程 生物材料工程
  • 材料科学 材料科学 材料科学
  • 医疗器械 医疗器械

背景情况:

  • 大自然利用平行管状结构在植物中有效的流体运输.
  • 平行通道结构激发了流体管理和血静的新设计.
  • 出血仍然是创伤相关死亡的主要原因,需要先进的静血解决方案.

研究的目的:

  • 开发一个微型热电半导体PN模块,用于创建梯度和并行通道的水凝.
  • 为了研究这些工程水凝的液体吸收率,形状记忆力学和静血性能.
  • 证明开发的设备在各种聚合物溶液中具有普遍适用性.

主要方法:

  • 制造小型热电半导体PN模块.
  • 快速冷却聚合物溶液 (在5分钟内从20°C降至-20°C),以诱导水凝的形成.
  • 描述水凝的特性,包括孔隙性,膨胀率,液体吸收和血液吸收.
  • 在体外和体内评估血静性能使用原-高平行通道泡.

主要成果:

  • 迷你热电模块成功地从各种聚合物中创建了梯度和并行通道的水凝.
  • 工程泡呈现出高孔度 (96.43%) 和快速膨胀 (2934%).
  • 与随机多孔泡相比,水凝表现出优异的液体吸收 (37.25倍自身重量),吸收速度 (46.5倍) 和血液吸收 (24倍),从而导致有效的止血.

结论:

  • 开发的迷你热电半导体模块可以制造先进的平行通道水凝.
  • 这些水凝具有显著的液体吸收和形状记忆性能.
  • 工程水凝显示出在紧急医疗中实现快速有效的血液静止的巨大潜力.