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在客观定义的微妙认知衰退的人群中,功能连接网络的改变

Xinyi Zhang¹, Qingze Zeng², Yanbo Wang¹

¹Department of Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 310009, Hangzhou, China.

Brain communications

|March 1, 2024

概括

患有微妙认知衰退的个体显示大脑功能连接性增加,这表明阿尔茨海默病风险更高. 随着时间的推移,它们的功能网络下降得更快,突出显示了早期干预的必要性.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
医疗成像医学成像

背景情况:

微妙的认知衰退 (SCD) 表示阿尔茨海默病 (AD) 的风险增加.
在SCD中大脑功能变化仍然不太了解.
对SCD的客观定义对于早期风险评估至关重要.

研究的目的:

在客观定义的微妙认知衰退 (oSCD) 中调查功能网络模式.
在oSCD中检查横截面和纵向大脑功能连接.
与AD生物标志物和认知表现相关联功能网络指标.

主要方法:

利用了来自阿尔茨海默氏病神经成像计划 (ADNI) 队列的静止状态功能性MRI (fMRI) 数据.
包括认知正常 (CN),客观定义的微妙认知衰退 (oSCD) 和轻度认知障碍 (MCI) 的参与者.
计算的中心度和自向量中心度;使用ANCOVA进行横截面和重复测量,使用ANCOVA进行纵向分析.

主要成果:

观察到自身向量中心性 (左上旋) 和度中心性 (左前) 的显著群体间差异.
oSCD组表现出自向量中心性和度中心性随时间推移的最快下降率.
在oSCD中增加的功能连接与AD病理和认知功能措施相关.

结论:

客观定义的微妙认知衰退个体显示大脑功能连接的改变.
这些变化与阿尔茨海默氏症进展标志物有关.
oSCD个体在功能性大脑网络中经历了更快的下降,这凸显了他们的AD风险增加.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.中心性的程度.自向量中心性自向量中心性功能连接性的功能连接性客观定义的微妙认知能力下降.

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