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基于TBSS方法的冠状动脉疾病患者大脑白质变化的扩散皮质成像

Tong Li¹, Rui Qin¹, Cuicui Li¹

¹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Frontiers in aging neuroscience

|March 1, 2024

概括

冠状动脉疾病患者表现出白质微观结构的变化,包括辐射收缩和复杂性,可通过扩散曲解成像 (DKI) 检测到. 这些发现与认知障碍相关,为辅助诊断提供了潜力.

科学领域:

神经成像是一种神经成像.
放射学放射学是一门学科.
心脏病学心脏病学

背景情况:

冠状动脉疾病 (CAD) 越来越多地与认知障碍 (CI) 相关.
在患有CI的CAD患者中,潜在的白质微观结构变化仍然不完全理解.
扩散曲解成像 (DKI) 为白质完整性提供了先进的见解.

研究的目的:

用DKI研究CAD和CI患者的白质微结构变化.
在这个人群中探索DKI参数与认知功能之间的相关性.

主要方法:

28名CAD患者和30名健康对照 (HC) 接受了扩散序列头部成像.
包括FA,KFA,MK,AK,RK和MD在内的DKI参数是使用DKE软件生成的.
进行了基于通道的空间统计 (TBSS) 和与认知得分 (MMSE,MoCA) 的相关性分析.

主要成果:

与HC相比,CAD患者在各种白质通道中显示了FA,KFA,MK和RK的显著减少.
在冠状辐射体,体和内部囊中注意到了具体的减少.
内部囊的右后肢和大脑脚中的FA值与MMSE得分呈正相关.

结论:

患有CAD的患者表现出辐射收缩和大脑白质微观结构的复杂性.
全脑TBSS DKI分析客观地反映了CAD患者的白质损伤.
DKI为CI的CAD的辅助诊断提供了基础.

关键词:

这就是为什么MRI是MRI.认知障碍是一种认知障碍.冠状动脉疾病是一种冠状动脉疾病.扩散曲解成像扫描图像基于面积的空间统计数据.

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