评估精神疾病和阻塞性睡眠呼吸暂停之间的因果关系:双向的门德尔随机化
Chuanhao Mi1, Ajiao Hou2, Yinqin Liu1
1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Frontiers in psychiatry
|March 1, 2024
概括
大型抑郁症 (MDD) 因果关系增加了阻塞性睡眠呼吸暂停 (OSA) 的风险. 这项遗传研究没有发现OSA导致MDD的证据,突出了减少睡眠呼吸暂停发病率的潜在目标.
科学领域:
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 观察性研究表明,精神疾病 (PD) 和阻塞性睡眠呼吸暂停 (OSA) 之间存在联系.
- 之前还没有研究过PDs和OSA之间的因果关系.
- 这项研究调查了PD和OSA之间的潜在因果关系.
研究的目的:
- 为了检查精神疾病和阻塞性睡眠呼吸暂停之间的因果关系.
- 为了确定对PDs的遗传倾向是否影响OSA风险.
- 为了调查从OSA到PD的逆因果关系.
主要方法:
- 孟德尔随机化 (MR) 分析使用来自FinnGen和精神病基因组学联盟 (PGC) 的总结遗传数据.
- 采用逆变量加权 (IVW),MR-Egger,加权中位数和加权模式方法.
- 进行敏感性分析和多变量MR (MVMR) 以评估协会的稳定性和独立性.
主要成果:
- 基因预测的大型抑郁症 (MDD) 显著增加了OSA的风险 (IVW OR: 1.377,P = 1.05×10−9).
- 敏感性分析表明没有显著的性或异质性.
- 在对MVMR中BMI,吸烟和酒精进行调整后,MDD和OSA之间的关联仍然显著.
- 在反向MR分析中没有观察到OSA对PD的因果作用.
结论:
- 重度抑郁症 (MDD) 对阻塞性睡眠呼吸暂停 (OSA) 的风险具有因果关系.
- 研究结果表明,针对MDD可能有助于减少OSA发病率.
- 需要进一步的研究来阐明MDD-OSA关系背后的机制.
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