怀孕中血液学特征和凝血病随着COVID-19继承第一波:一个多中心的回顾性横截面研究
Maha Othman1,2,3, Georgiana Nemeti4,5, Marissa Solow6
1Department of Biomedical and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Research and practice in thrombosis and haemostasis
|March 1, 2024
概括
怀孕期间的COVID-19没有显示出显著的凝血病,尽管炎症增加. 虽然出血风险很低,但严重的疾病需要对孕妇的血栓预防进一步研究.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 以前的报道将COVID-19与怀孕期间的凝血病和静脉血栓栓塞有关.
- 有关SARS-CoV-2变种并发症和疾病严重程度增加的担忧存在.
- 有限的数据评估了这些风险在后来的流行病浪潮.
研究的目的:
- 分析受COVID-19影响的怀孕中的血液学特征.
- 评估COVID-19感染孕妇的出血和血栓并发症.
- 评估与新出现的SARS-CoV-2变种相关的风险.
主要方法:
- 追溯性,跨国队列研究.
- 涉及加拿大,罗马尼亚和英国的370名患者.
- 分析了血液学标记,炎症和内皮功能障碍.
主要成果:
- 观察到炎症和内皮功能障碍标志物的升高.
- 没有发现明显的COVID-19相关的凝血病,即使是严重的疾病.
- 静脉血栓栓塞的风险较低;与纤维素素 <2g/L 相关的产后出血.
结论:
- 关于低出血和血栓性并发症发生率的研究结果令人放心.
- 在怀孕期间严重的COVID-19需要进一步调查血栓预防.
- 孕妇COVID-19患者的血液学概况得到了更好的理解.
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