对与艾滋病毒-1感染的加纳人的微生物组合的纵向分析
Lucky Ronald Runtuwene1,2, Prince Kofi Parbie3,4, Taketoshi Mizutani2,5
1AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Frontiers in microbiology
|March 1, 2024
概括
人类免疫缺陷病毒 (HIV) 感染导致肠道微生物组发生变化. 尽管接受了治疗,肠道内膜可能仍然受到损害,与艾滋病毒进展和肠道健康相关的特定细菌的水平发生了变化.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染与肠道微生物群失调有关.
- 艾滋病毒-1感染肠道CD4+T细胞,破坏肠道粘膜的稳定.
- 艾滋病毒对肠道微生物群失生症的影响即使在抗逆转录病毒治疗中也持续存在.
研究的目的:
- 研究艾滋病毒感染者肠道微生物群多样性和组成的纵向变化 (PLWH).
- 为了将微生物组的变化与临床参数相关联,例如CD4+T细胞计数和抗逆转录病毒治疗持续时间.
主要方法:
- 在基线和六个月后对PLWH的纵向微生物组分析.
- 在PLWH和健康对照组之间对肠道微生物组进行比较.
- 微生物属丰度与临床数据 (CD4+T细胞数量,可溶性CD14,抗逆转录病毒持续时间) 之间的相关性分析.
主要成果:
- 肠道微生物群多样性在六个月内在PLWH中显示部分恢复,但仍然低于对照组.
- 特定的细菌系,包括与艾滋病毒进展相关的细菌 (Achromobacter, Stenotrophomonas) 和肠道保护 (Akkermansia),在改变的丰度中被发现.
- CD4+ T细胞计数和可溶性CD14水平与微生物群多样性指数相关.
- 抗逆转录病毒治疗的持续时间影响了某些细菌种的丰富性.
结论:
- 尽管临床标志物有所改善,但PLWH中的肠粘膜可能仍然受到损害.
- 潜在有害和保护性肠道细菌的共同丰富表明正在进行的肠道屏障功能障碍.
- 微生物组分析提供了关于艾滋病毒感染对肠道健康持续影响的见解.
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