血清分泌的蛋白1水平与冠状动脉疾病患者的斑块脆弱性有关
Ke Huang1,2, Shuai Chen1,2, Lin-Jun Yu1,3
1Department of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China.
Frontiers in immunology
|March 1, 2024
概括
分泌蛋白1 (SPP1) 的血清水平升高表明冠状动脉疾病患者的斑块脆弱性增加. 这种生物标志物可以帮助预测易受损伤的斑块的风险,这些斑块与心血管事件有关.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 冠状动脉疾病中的易受损伤的斑块与反复发生的心血管事件有关.
- 识别易受损性斑块的预测生物标志物对于患者管理至关重要.
研究的目的:
- 探索冠状动脉疾病患者易受损伤的斑块的预测生物标志物.
- 在脆弱的斑块发育中识别表型相关的细胞类型和枢纽基因.
主要方法:
- 结合单细胞RNA和大量RNA测序数据使用剪刀和WGCNA.
- 在使用血管内超声波的独立队列中验证了这些发现.
- 在大量患者队列中分析了已识别的生物标志物的血清水平.
主要成果:
- 大细胞与斑块脆弱性相关;VSMC,FC和ICS群体显示出负相关性.
- 分泌蛋白1 (SPP1) 被确定为一个枢纽基因,与斑块脆弱性高度相关.
- 患有脆弱斑块 (p < 0.001) 的患者血清SPP1水平升高显著更高,并独立预测其存在 (AUC = 0.737).
结论:
- 血清SPP1水平升高会增加冠状动脉疾病中斑块脆弱性的风险.
- 血清SPP1是一种有前途的独立生物标志物,用于预测易受损伤的斑块.
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