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Updated: Jul 1, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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使用WGCNA对性结肠炎关键基因的鉴定和免疫透分析

Siyi Ni1, Yingchao Liu1, Jihong Zhong1

  • 1Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

PeerJ
|March 1, 2024
PubMed
概括

研究人员确定了五个关键基因,ABCG2,IL1RN,REG4,SERPINB5和TRIM29,参与性结肠炎 (UC) 病原体. 在UC小鼠模型中证实了基因表达变化,为炎症性肠病提供了洞察力.

关键词:
生物信息学分析免疫透分析分析性结肠炎是一种在WGCNA中,WGCNA是WGCNA.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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