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接近与非酒精性胆固醇肝炎相关的肝硬化患者

Paolo Gallo¹, Valentina Flagiello¹, Andrea Falcomatà¹

¹Operative Research Unit of Clinical Medicine and Hepatology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma, Italy.

Journal of clinical and translational hepatology

|March 1, 2024

概括

肉症或肌肉损失在慢性肝病 (CLD) 中很常见. 与代谢功能障碍相关的肥胖性肝病 (MASLD) 的增加意味着类病经常与肥胖症并存,使患者的结果恶化.

科学领域:

肝病学肝病学是一种肝病学.
老年病的医生老年病的医生
代谢障碍代谢障碍代谢障碍

背景情况:

肉症是慢性肝病 (CLD) 的常见并发症,特别是在肝硬化中.
与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,越来越普遍,并与肥胖和肉症有关.
萨尔科佩尼亚和MASLD之间的相互作用导致不良结果,包括肝肌脂肪组织轴的放松调节.

研究的目的:

审查代谢功能障碍相关的脂肪性肝病 (MASLD) 中的萨尔科佩尼亚的新兴情景.
为了突出萨尔科佩尼亚和MASLD中糟糕的结果之间的关联.
讨论在MASLD中对萨尔科佩尼亚的潜在治疗策略.

主要方法:

文献综述,重点关注慢性肝病和MASLD中的肉类.
在MASLD和肉症的背景下分析肝-肌肉-脂肪组织轴.
讨论当前的知识差距和未来的研究方向.

主要成果:

在与MASLD相关的CLD的背景下,sarcopenia经常与肥胖症共存.
麻症和MASLD之间的相互作用与增加的发病率和死亡率有关.
目前尚缺少针对MASLD中肉症的具体治疗指南.

结论:

在MASLD中,对肉类的有效管理策略应侧重于减少脂肪质量,同时保持瘦体质量.
饮食干预,营养补充和体育炼是有希望的方法.
需要进一步的研究,以建立最佳的评估和治疗方案,在MASLD. sarcopenia.

关键词:

肝硬化是肝硬化的一种疾病.马斯尔德马斯尔德是什么意思这是NAFLD.萨尔科佩尼亚是什么意思萨尔科佩尼亚标本性肥胖症标本性肥胖症

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