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Updated: Jul 1, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050

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晶体结构和Geobacillus stearothermophilus S9酶的溶液散射揭示了对碳氧酶活动的结构适应

Khileshwari Chandravanshi1, Rahul Singh2, Gauri N Bhange2

  • 1Department of Bioscience and Biomedical Engineering, Indian Institute of Technology Indore, India.

FEBS letters
|March 1, 2024
PubMed
概括

乙氨基酶 (AAPs) 是治疗的目标. 这项研究揭示了Geobacillus stearothermophilus AAP (S9gs) 作为一种罕见的碳氧酶而不是氨基酶,具有独特的结构适应性.

关键词:
N-乙化 N-乙化亚氨基酸酸盐是什么碳氧酸酸酶是什么宁氨酸是什么 宁氨酸普罗利尔寡酸酶的使用.

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Allosteric Proteins-ATCase01:19

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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