系统炎症反应指数或系统免疫炎症指数可以预测孕期糖尿病在头三个月吗? 一个前性的观察性研究
Esra Gulen Yildiz1, Atakan Tanacan1, Gulcan Okutucu1
1Division of Perinatology, Department of Obstetrics and Gynecology, Ankara City Hospital, Ankara, Turkey.
概括
新的炎症指数系统免疫炎症指数 (SII) 和系统炎症反应指数 (SIRI) 显示出早期妊娠糖尿病 (GDM) 预测的前景. 这些标记物可以作为常规临床实践的宝贵补充,用于第一季度GDM查.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 孕期糖尿病 (GDM) 对母亲和胎儿的健康构成风险.
- 早期预测GDM对于及时干预和改善结果至关重要.
- 现有的预测标记在早期检测怀孕时可能存在局限性.
研究的目的:
- 评估系统性免疫炎症指数 (SII) 和系统炎症响应指数 (SIRI) 在预测第一季度GDM中的有效性.
- 在GDM预测中确定SIRI和SII的最佳切断值.
- 评估其他炎症标志物与第一季度GDM的关联.
主要方法:
- 一项前性观察研究包括94名患有GDM的孕妇和107名健康对照.
- 在GDM和对照组之间比较了第一季度SIRI和SII值.
- 使用接收器操作特征 (ROC) 曲线分析来确定预测切断水平.
主要成果:
- 在GDM组中,第一季度SIRI和SII值显著升高 (P<0.001).
- 对SIRI和SII的最佳截止值显示了适度的预测性能 (AUC分别为0.71和0.70).
- 在GDM组中也观察到中性粒细胞计数,MPV,NLR和RDW的增加.
结论:
- SII和SIRI是潜在的新型炎症指数,可以预测孕妇在头三个月的GDM.
- 它们在预测GDM胰岛素需求中的作用似乎有限.
- 这些指数可以作为常规临床实践中用于早期GDM检测的补充工具.
更多相关视频
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
221
06:46A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
2.8K
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Pathophysiology of Diabetes
928
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
928
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Diabetes: Symptoms, Diagnosis, and Complications
534
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
534
