相关实验视频
Updated: Jul 28, 2026

07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
12.5K
关于小细胞转移性膀癌的定义,结果和前景:朝着标准化术语的方向
Giorgio Calleris1,2, Markus von Deimling3,4, Claudia Kesch1,5
1Department of Urology UROSUD, La Croix du Sud Hospital, Quint-Fonsegrives, France.
Current opinion in urology
|March 1, 2024
概括
低甲状腺 (OM) 膀癌 (BCa) 是一种可用组合疗法治疗的过渡状态. 最近的发现表明,多模式治疗,包括手术和转移导向疗法 (MDT),可以改善选择的omBCa患者的生存率.
科学领域:
- 尿瘤学 尿瘤学
- 癌症转移 癌症转移
- 多模式癌症治疗疗法 多模式癌症治疗
背景情况:
- 寡甲状腺 (OM) 癌症代表局部疾病和广泛转移之间的中间阶段.
- 目前对尿道膀癌 (BCa) 的定义和治疗方法缺乏标准化,严重依赖于回顾性数据.
- 标准化术语和基于证据的方法对于管理omBCa至关重要.
研究的目的:
- 为了建立一个框架,在omBCa. uro-oncologic术语的框架.
- 审查有关OMBCa治疗的最新证据.
- 讨论omBCa研究和治疗的未来前景.
主要方法:
- 对回顾性和注册表数据的审查.
- 对omBCa定义 (2023) 的Delphi共识的分析.
- 对转移导向治疗 (MDT) 结果的元分析.
- 检查匹配的注册表分析和队列研究.
主要成果:
- 追溯数据支持选择的omBCa患者多模式治疗的益处.
- 2023年德尔菲共识将omBCa定义为具有最多三种转移性病变,可接受局部治疗.
- 在 de-novo omBCa 中,初级瘤手术和巩固性放射治疗可以改善整体存活率 (OS).
- MDT显示了高的局部控制率和有前途的OS (14.9-51个月),特别是单位,节点或肺转移.
结论:
- 在 de-novo omBCa 中,对原发性和转移性部位的局部治疗可能会提高选择患者的疾病控制和存活率.
- 在少量流行的环境中,MDT提供了良好的症状控制,具有有限的副作用和潜在的生存益处.
- 需要前性证据来验证发现,以最近建立的omBCa.的共享定义为指导.
相关概念视频
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...

