药物对三项瑞典老化纵向研究中的功能性生物标志物的作用
Thaís Lopes De Oliveira1,2, Bowen Tang1, Ge Bai1,3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Aging cell
|March 1, 2024
概括
常见的药物,如上腺激素/吸入剂和脂质修饰剂,可能会改善认知功能. 选择性通道阻断剂可能会改善功能衰老,但对脆弱性没有发现好处. 需要进一步的研究.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 针对高血压,脂质和血糖的药物在动物模型中显示出减缓衰老的前景.
- 人类研究有限,随访时间短,关于药物对衰老的影响的结果不确定.
- 了解常用药物对衰老生物标志物的影响,对公共卫生至关重要.
研究的目的:
- 调查常规处方药对老年人的功能衰老,认知功能和虚弱的影响.
- 使用纵向人口数据估计21种常见药物组对衰老生物标志物的影响.
- 为药物在调节人类衰老过程中的潜在作用提供证据.
主要方法:
- 利用了来自瑞典三项基于人口的纵向研究 (1986-2014) 的数据,其中包括1191-1361名65岁以上的参与者.
- 采用自控分析,通过调整时间稳定的个体特征来减轻混.
- 进一步调整时间变化的混因素,包括年龄,并发症指数,吸烟,BMI和药物数量.
主要成果:
- 上腺体/吸入剂 (效果大小=0.089) 和脂质修饰剂/平淡剂 (效果大小=0.082) 与改善的认知功能有关.
- 选择性通道阻断剂 (血管效应) 与较低的功能衰老指数 (改善,效果大小=-0.129) 有关.
- 在研究的药物组中,没有观察到对脆弱指数的显著有益影响.
结论:
- 一些常用的药物,包括上腺激素/吸入剂和脂质修饰剂,可能会积极影响认知功能.
- 选择性通道阻断剂显示出改善功能衰老标志物的潜力.
- 目前的证据不支持对脆弱的有益影响,强调需要进一步临床研究药物在健康衰老中的作用.
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