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Updated: May 10, 2026

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
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一个基于NMR的新型协议,用于选超低分子量碎片

Annagiulia Favaro1, Mattia Sturlese1

  • 1Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131 Padova, Italy.

Journal of medicinal chemistry
|March 1, 2024
PubMed
概括

超低分子量 (ULMW) 碎片提供了一个有效的药物发现策略. 这项研究引入了一种新的核磁共振 (NMR) 协议,以检测这些MiniFrags与人类Bfl-1蛋白的弱相互作用.

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