DHEA:一种被忽视的生物信号,可能会影响胎儿和儿童的发育
Natasha A Bailey1, Elysia Poggi Davis2,3, Curt A Sandman4
1Department of Psychology, University of Virginia, Charlottesville, VA, USA.
概括
在怀孕期间,母亲的脱水氨 (DHEA) 和皮质醇水平会影响婴儿的情绪反应. 较高的DHEA与正反应性有关,而高的皮质醇与负反应性有关,特别是当DHEA低时.
科学领域:
- 神经内分泌学神经内分泌学
- 发展心理学 发展心理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 通过皮质醇,母亲的下丘脑-垂体-上腺 (HPA) 轴会影响胎儿的神经发育.
- 另一种HPA轴产物脱氨 (DHEA) 在人类怀孕研究中被忽视.
- 产前母亲的DHEA和皮质醇对后代神经发育的联合影响在很大程度上是未知的.
研究的目的:
- 为了研究产前母亲的DHEA和皮质醇对婴儿情绪反应的联合作用.
- 探索DHEA作为胎儿编程中的生物信号的潜在作用.
- 检查DHEA如何调节皮质醇对婴儿情绪结果的影响.
主要方法:
- 研究了124个母婴二合体.
- 在怀孕15周和35周收集的母亲头发样本测量了DHEA和皮质醇.
- 婴儿的情绪反应 (积极和消极) 在6个月评估.
主要成果:
- 孕期早期和晚期母体DHEA升高与婴儿积极情绪反应的增加相关.
- 更高的孕期晚期母性皮质醇与婴儿更大的负面情绪反应性有关.
- 母亲皮质醇和婴儿情绪反应之间的关联只有当母亲的DHEA水平较低时才显著.
结论:
- 在产前编程中,DHEA是重要的孕产妇生物信号,独立和与皮质醇一起起作用.
- 母亲的DHEA水平似乎影响婴儿的情绪反应,可能缓冲或加剧皮质醇的影响.
- 关于胎儿编程的未来研究应该将DHEA与皮质醇一起纳入综合理解中.
相关概念视频
01:24Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
01:18Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
01:22Target Cell Response to Hormones
3.0K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
3.0K
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
01:27Major Hormones and Their Functions
392
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
392
01:08Chemical Signaling in the Endocrine System
3.2K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
3.2K