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转录和干预证据显示,家养狗是抗炎研究的有希望的模型

Min Zeng^1,2, Tong Zhou¹, Zhiyu Li³

¹Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

|March 1, 2024

概括

作为老龄化模型,家养狗显示出有前途的承诺. RNA测序确定了与年龄相关的基因,抗衰老治疗减少了老犬的炎症并改善了心脏功能.

科学领域:

老年学和比较基因组学.
兽医和衰老研究.

背景情况:

养狗提供了一个独特的机会来研究衰老,因为它们与人类共享的环境和寿命.
了解狗的衰老模式可以为哺乳动物的衰老过程提供洞察力.

研究的目的:

为了描述不同年龄段的家养狗的转录基因模式.
评估狗作为老化研究模型生物的潜力.
评估老年狗的抗衰老干预措施的有效性.

主要方法:

在1-9岁的狗的白细胞上进行了RNA测序.
老狗接受了犬类介质干细胞 (cMSCs),尼古丁胺胺单核酸和拉帕素的治疗.
分析了与年龄相关的基因表达和炎症标志物.

主要成果:

确定了61个与年龄相关的基因,主要与新陈代谢和免疫功能有关.
抗衰老疗法显著降低了炎症因素 (IL-6和TNF-α).
在老狗中,cMSCs改善了心脏功能,并逆转了与年龄相关的关键基因 (PYCR1,CCRL2,TOX).

结论:

家庭狗表现出与衰老一致的转录组模式,支持它们作为衰老模型的使用.
抗衰老干预措施显示出缓解与年龄相关的衰退,特别是炎症的潜力.
狗介质干细胞在狗的老化相关疾病中显示出治疗效益.

关键词:

与年龄相关的基因衰老的衰老衰老的衰老这是一种抗炎药,是一种抗炎药.狗中介细胞干细胞狗中介细胞干细胞狗模型狗模型狗模型

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