在中度至重度的持续性喘中发生反应逆转:低出生体重,早产效应和支气管扩展剂反应
Ramiro González Vera1, Alberto Vidal Grell2, José A Castro-Rodríguez3
1Clínica Las Condes, Santiago, Chile.
概括
反应率逆转 (RI) 在患有严重喘的儿童中很常见,特别是那些早产的儿童. 持续的RI表明肺功能较差,可能表明小呼吸道功能障碍.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 喘研究 喘研究
背景情况:
- 反应力逆转 (RI) 与持续性喘中外围气道功能受损有关.
- 有限的数据存在于临床和肺功能差异之间的喘儿童与没有RI.
研究的目的:
- 为了确定中度至重度喘儿童的临床和肺功能差异,有或没有RI.
主要方法:
- 在2021-2022年期间与学龄喘儿童进行.
- 根据ATS/ERS标准使用脉冲振荡计 (IOS) 和螺旋计.
- 将62名患者分为三个组:没有RI,短暂RI和持久RI.
主要成果:
- 患有RI的儿童 (第2组和第3组) 的出生体重和妊娠年龄低于没有RI的儿童 (第1组).
- 第二组和第三组的FEV1和FEF25-75.5显著降低.
- 持久性RI (3组) 与较高的R5,AX,R5-20,R5-R20/R5值和较低的支气管扩展剂反应相关.
结论:
- RI在中度至重度的持续性喘中普遍存在,特别是在那些有早产或低出生体重史的人群中.
- 虽然RI可以解决支气管扩张后的情况,但持续的RI与肺功能恶化有关.
- 在儿科喘中,RI可能作为小呼吸道功能障碍的标志物.
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