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Updated: Jul 1, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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激素SAM酶PylB通过使用SAM作为辅因子在Pyrrolysine的生物合成中产生基中间体

Baixu Ma1, R David Britt2, Lizhi Tao1

  • 1Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.

Journal of the American Chemical Society
|March 1, 2024
PubMed
概括

研究人员阐明了PylB的机制,PylB是一种关键的酶,用于氨酸 (第22种氨基酸) 的生物合成. 他们证明S-adenosyl-l-methionine (SAM) 作为一种催化辅助因子,揭示了这种必不可少的古代途径中的基中间体.

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