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中线入侵预测扩散半球质瘤的预后不佳,H3G34突变:个体参与者数据审查

Yasuhito Kegoya¹, Yoshihiro Otani², Yohei Inoue¹

¹Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, 700-8558, Okayama-shi, Okayama, Japan.

Journal of neuro-oncology

|March 1, 2024

概括

在MRI上,中线入侵 (MI) 表明扩散半球质瘤,H3 G34突变 (DHGs) 的预后更差. 这种成像发现是这些儿科类型高度质瘤的整体存活期的独立预后因素.

科学领域:

神经瘤学神经瘤学
儿科瘤学儿科瘤学
放射学放射学是一门学科.

背景情况:

扩散半球质瘤,H3G34突变 (DHGs) 是世卫组织的4级瘤,预后不佳.
关于DHG的临床表现的研究有限,特别是成像发现.
这项研究调查了成像发现及其与DHGs预后的关系.

研究的目的:

探索临床因素之间的关系,包括成像检测结果,以及 DHGs 患者的预后.
为了确定与DHGs的整体存活率相关的成像特征.

主要方法:

在Medline/PubMed的系统文献搜索"G34"和"结质瘤" (2012年4月-2023年7月).
包括96名患者,在MRI上定义中线入侵 (MI) 作为入侵特定的大脑结构.
使用卡普兰-梅尔曲线和后勤回归分析了12个月的生存率.

主要成果:

额叶病变最常见 (52.6%);39.6%的患者患有心脏病发作.
平均整体存活时间 (OS) 为14.4个月.
与MI阴性患者相比,MI阳性患者的生存状况明显差,MI被确定为独立的预后因素.

结论:

在MRI上,中线入侵 (MI) 与DHGs的更差预后有关.
肌痛性心脏病作为一个重要的独立预后因素,用于DHGs的整体存活率.
像MI这样的成像发现对于预测DHGs的结果至关重要.

关键词:

分散半球质瘤,H3 G34突变额叶叶子额叶叶子总体切除的总体切除.中线入侵中线入侵

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