相关实验视频

Updated: Jul 1, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

由WT1疫苗接种诱导的长达十年的WT1特异性CTLs

Tatsuya Suwabe¹, Yasuhiko Shibasaki², Suguru Tamura²

¹Department of Hematopoietic Stem Cell Transplantation, Niigata University Medical and Dental Hospital, Niigata, Japan.

International journal of hematology

|March 1, 2024

概括

威尔姆斯瘤1 (WT1) 类疫苗接种在慢性髓性白血病 (CML) 患者中产生持久的细胞毒性T淋巴细胞 (CTLs). 这些特异于WT1的CD8+T细胞持续超过10年,显示出持续的抗癌免疫力.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
疫苗学疫苗学疫苗学

背景情况:

针对威尔姆斯瘤1 (WT1) 的基于类的癌症疫苗在血液恶性瘤中表现有前途.
疫苗接种后WT1特异性CD8+细胞毒性T淋巴细胞 (CTLs) 的长期持续性和程度尚不清楚.

研究的目的:

在患有慢性髓性白血病 (CML) 的患者中,研究疫苗接种后WT1特异性CTLs的长期持久性.
分析这些持久性CTLs的T细胞受体 (TCR) 谱和功能性细胞毒性.

主要方法:

将WT1疫苗给一个CML患者.
在接种疫苗后的12年内进行长度免疫监测.
使用下一代测序对WT1特定的CTL和TCR目录分析进行特定放大.

主要成果:

在低频率下 (少于5个细胞/1,000,000个CD8+T细胞) 持续超过10年.
接种疫苗后的11年,TCR系列分析证实了WT1特异性CTL的多样性.
实验室试验证明了CTLs的WT1特定细胞毒性.

结论:

在CML患者中,WT1疫苗诱导了持久的免疫反应.
在停止接种疫苗后,WT1 特定的 CD8+ CTL 可以持续超过十年.
这项研究突出了WT1疫苗长期免疫治疗功效的潜力.

关键词:

癌症类疫苗疫苗癌症类疫苗慢性骨髓性白血病慢性骨髓性白血病免疫测试是一种免疫测试.在TCR的曲目中,TCR的曲目包括:威尔姆斯瘤11号威尔姆斯瘤11号

更多相关视频

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

相关概念视频

Vaccinations

Vaccinations

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...