在参与弗雷明汉心脏研究的参与者中,教育流动性,衰老速度和寿命
Gloria H J Graf1,2, Allison E Aiello1,2, Avshalom Caspi3,4,5,6
1Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.
JAMA network open
|March 1, 2024
概括
更高的教育程度与缓慢的生物衰老和更长,更健康的生活有关. 这项研究发现,上升的教育流动性与降低的死亡风险有关,而较慢的衰老解释了大约一半的好处.
科学领域:
- 老年学是指老年学的学科.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 高等教育与改善健康和长寿有关.
- 有证据表明,这种关联可能是由生物衰老的速度减慢调解的.
- 测量生物衰老可以为教育干预研究提供中间终点.
研究的目的:
- 研究教育上升流动性与生物衰老的速度之间的关联.
- 为了确定教育流动是否与延长寿命有关.
- 探索生物衰老在调解教育与寿命之间的关系中的作用.
主要方法:
- 使用三代弗雷明汉心脏研究参与者的前性队列研究.
- 通过比较参与者的教育与他们的父母的教育来量化代际教育流动性.
- 用DNA甲基化数据和DunedinPACE表观遗传钟来测量生物衰老,并得到其他四个钟的验证.
主要成果:
- 教育上升的流动性与生物衰老的速度减慢有关 (r = -0.18,P < .001).
- 这种关联在跨世代和兄弟姐妹的比较中是一致的.
- 上升教育流动与降低死亡风险有关 (HR = 0.89,P = .01),老龄化速度减缓约占这一影响的一半.
结论:
- 研究结果支持这样一个假设,即教育成就干预措施可能会减缓生物衰老并促进长寿.
- 表观遗传钟显示出作为健康衰老干预措施的中间结果措施的希望.
- 需要进一步的实验研究来证实这些关联.
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