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放射治疗通过诱导PD-L1和MDSC在远端部位通过免疫抑制增强转移

Yuzhu Hou^1,2,3, Kaiting Yang^2,3, Liangliang Wang^2,3

¹Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, ShaanXi, China.

Clinical cancer research : an official journal of the American Association for Cancer Research

|March 1, 2024

概括

放射治疗可以增加骨髓衍生抑制细胞 (MDSC) 和PD-L1表达,促进癌症转移. 抑制这些因素可以通过减少瘤扩散来改善患者的治疗结果.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
放射治疗研究放射治疗研究

背景情况:

放射治疗 (RT) 是癌症治疗的基石.
新出现的证据表明,RT可以对免疫系统产生双重影响,可能促进瘤生长.
了解RT诱导的免疫抑制对于优化癌症治疗至关重要.

研究的目的:

为了研究放射治疗引起的免疫抑制因素.
阐明RT可能促进瘤转移的机制.

主要方法:

利用异质的两种瘤模型,消除了适应性并发免疫.
分析了编程死亡连接体1 (PD-L1) 表达和骨髓衍生抑制细胞 (MDSC) 频率.
采用患者外周血液单核细胞和小鼠转移模型.

主要成果:

局部照射导致免疫细胞MDSC和PD-L1表达的系统性增加.
RT增强了非辐射组织中转移传播的潜力.
通过电离辐射诱导PD-L1与CXCL10化学激素信号传递有关.

结论:

放射治疗可以诱导全身免疫抑制,增加转移风险.
针对PD-L1/CXCL10轴或MDSC透可以减轻RT诱导的转移.
阻止这些途径的干预措施可以改善abscopal瘤控制和患者的结果.

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