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高中期和高风险子宫内膜癌中哨戒节点映射:对5年瘤结果的分析

Ilaria Cuccu¹, Francesco Raspagliesi², Mario Malzoni³

¹Gynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy; Department of Gynecological, Obstetrical and Urological Sciences, 'Sapienza' University of Rome, Italy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|March 1, 2024

概括

哨兵节点映射是对高风险子宫内膜癌的系统淋巴切除术的安全替代方案,显示了类似的5年生存结果. 这种方法不会对这些患者的生理结果产生负面影响.

科学领域:

妇科瘤学妇科瘤学
手术瘤学手术瘤学
癌症研究癌症研究

背景情况:

子宫内膜癌的分期通常涉及淋巴切除术,这是一种与患病率相关的程序.
哨兵淋巴结 (SLN) 映射正在成为一种不那么侵入性的分期技术.
在高中期和高风险子宫内膜癌中SLN映射的瘤安全性需要进一步评估.

研究的目的:

在早期,高中期和高风险子宫内膜癌中,对哨兵淋巴结 (SLN) 地图和系统淋巴切除术之间的5年瘤结果进行比较.
评估SLN绘图的安全性和有效性,作为全面淋巴切除术的替代方案.

主要方法:

多机构的回顾性,倾向匹配的研究.
包括基于ESGO/ESTRO/ESP指南的高中期和高风险子宫内膜癌患者.
70名接受SLN测绘的患者的结局与70名接受系统性淋巴切除术的患者的结局进行比较.

主要成果:

哨兵节点映射实现了单边 (100%) 和双边 (91.7%) 检测的高率.
在SLN映射和淋巴切除组之间,在5年无病生存率 (p=0.547) 或整体生存率 (p=0.256) 上没有显著差异.
在32.8%的患者中诊断出结节性疾病,SLN映射在10.9%的患者中识别出准大动脉结节性参与.

结论:

哨兵淋巴结映射在瘤学上相当于用于高中期和高风险子宫内膜癌的系统淋巴切除术.
SLN映射不会对5年生存结果产生不利影响.
建议进行前性研究,以进一步验证这些发现.

关键词:

这是子宫内膜癌的癌症.这是高风险的高风险.中高风险 - 中高风险哨兵节点映射的映射

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