通过碳基纳米酶的双催化,通过增强光动力学疗法的瘤微环境敏感化
Shuaipeng Feng1, Yan Xiao2, Junya Lu1
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China.
Journal of colloid and interface science
|March 1, 2024
概括
这项研究开发了合铜的空心碳纳米粒子 (CHC),通过保护光敏剂和使瘤微环境 (TME) 变得敏感来增强光动力疗法 (PDT),实现显著的瘤抑制和减少转移.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 光动力疗法 (PDT) 的有效性受到瘤微环境 (TME) 的抗氧化能力和光敏剂不稳定性所限制.
- 开发克服这些局限性的策略对于改善抗瘤结果至关重要.
研究的目的:
- 创建一个新的纳米平台,使用合铜的空心碳纳米粒子 (CHC) 进行增强的PDT.
- 为了保护光敏剂,同时通过谷氨耗尽和过氧化酶类活性对TME进行敏感化.
主要方法:
- 用Cu2+添加剂的空心碳纳米粒子 (CHC) 的制备和用氨酸 (HA) 涂层.
- 评估CHC的过氧化酶 (POD) 类活性和光热转换效率.
- 在体内评估联合光热-光动力学疗法 (PTT-PDT) 对瘤和转移的疗效.
主要成果:
- CHC显示POD类反应速度显著增加8.4倍.
- 氨酸涂层为TME中的催化部位提供了刺激响应的掩盖和揭示.
- 联合PTT-PDT实现了87.8%的瘤抑制率,并减少了74%的肺转移.
结论:
- 开发的基于CHC的平台有效地保护光敏剂,并通过调节TME来增强PDT.
- 这种综合方法显示了通过结合光热和光动力学效应来改善癌症治疗的巨大潜力.
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