预测放射治疗对老年乳腺癌患者的生存益处:基于人口的分析
Maoxian Li1, Jie Tang2, Xiudan Pan2
1Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
The Journal of surgical research
|March 1, 2024
概括
放射治疗有利于老年乳腺癌患者,改善生存结果. 新的预测工具有助于个性化管理癌症特异性存活率和这一人口群的整体存活率.
科学领域:
- 老年瘤学 老年瘤学
- 乳腺癌研究研究 乳腺癌研究
- 生存分析的分析.
背景情况:
- 老年乳腺癌患者 (70岁以上) 需要量身定制的治疗策略.
- 评估生存结果,包括癌症特异性生存率 (CSS) 和整体生存率 (OS),对这一群体至关重要.
- 放射治疗在老年乳腺癌患者中的作用需要进一步研究.
研究的目的:
- 在老年乳腺癌患者中开发和验证CSS和OS的预测工具.
- 评估放射治疗对生存结果的影响.
- 为临床医生提供更好的工具,以实现个性化的患者管理.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库 (2010-2018) 中对临床病理学数据的回顾性分析.
- 使用基于独立预后因素的考克斯比例风险模型开发名ograms.
- 使用一致性索引,接收器运行特征曲线 (AUC) 下的面积和校准图表验证名ograms.
主要成果:
- 分析了128,223名老年乳腺癌患者的队列,其中57,915人接受放射治疗.
- 在放射治疗和非放射治疗组中,名图显示出优异的区分和准确性,对CSS和OS的一致性指数>0.7.
- 与传统的瘤,结节,转移 (TNM) 阶段相比,开发的预测模型显示出更高的预测准确度.
结论:
- 放射治疗为老年乳腺癌患者提供了显著的生存益处.
- 开发的预测工具可以对CSS和OS进行个性化评估.
- 这些工具支持老年乳腺癌患者的个性化治疗决策和管理策略.
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