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Updated: Jul 1, 2025

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佐衍生物的独特结合方式为增加ERK2或p38αMAPK选择性提供了结构基础

Seisuke Hasegawa1, Mayu Yoshida1, Haruna Nagao2

  • 1Graduate School of Science, Osaka Metropolitan University, Osaka, 599-8570, Japan.

Biochemical and biophysical research communications
|March 1, 2024
PubMed
概括

一种针对细胞外信号调节激酶2 (ERK2) 的全抑制剂也抑制了p38α MAP激酶 (p38α MAPK). 结构分析显示,由于氨基酸差异,由于氨基酸差异而存在不同的结合模式,从而使选择性抑制剂的发展成为可能.

关键词:
艾洛斯特抑制剂 艾洛斯特抑制剂癌症 癌症 癌症 癌症晶体结构 晶体结构基因激活的蛋白质激酶激酶是由基因激活的.分子动力学分子动力学选择性的选择性

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