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Updated: May 5, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
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快速模拟葡萄糖蛋白结构通过移植和葡萄糖相容库的固体排除

Yu-Xi Tsai1, Ning-En Chang1, Klaus Reuter2

  • 1Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.

Cell
|March 1, 2024
PubMed
概括

GlycoSHIELD是一种新的计算方法,可以在蛋白质上模拟复杂的糖链 (glycans). 这种工具增强了个人电脑上的糖蛋白结构分析,帮助研究蛋白质功能.

关键词:
一个 GABAA受体甲基胺美国冠状病毒S蛋白化电磁场甘氨酸葡萄糖蛋白质质谱学分子动力学

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Oligosaccharide Assembly01:24

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Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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