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Updated: Jul 1, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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基于结构的非缩性阿佩林受体调节器设计

Wei-Wei Wang1, Su-Yu Ji1, Wenjia Zhang2

  • 1Department of Pharmacology and Department of Pathology of Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, China; Center for Structural Pharmacology and Therapeutics Development, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Cell
|March 1, 2024
PubMed
概括

研究人员设计了新的阿佩林受体 (APLNR) 激动剂WN353和WN561,以向心血管疾病. WN561对心脏缩的疗效有所提高,副作用较少,为新型心血管药物提供了潜力.

关键词:
亚佩林受体有偏差的信号传输化电磁结构药物设计心肌缩症其他副作用

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