后COVID-19条件对晚期慢性病患者造成重大负担:一个嵌套病例控制研究研究
Pim Bouwmans1, S Reshwan K Malahe2, A Lianne Messchendorp3
1Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands; CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, The Netherlands.
概括
晚期病患者面临着高症状负担的COVID-19后病情 (PCC) 的显著风险. 较低的抗体水平和COVID-19住院治疗增加了这种风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 在晚期病患者中,COVID-19后病情 (PCC) 负担尚未得到充分研究.
- 在SARS-CoV-2感染后的长期症状需要在脆弱人群中进一步调查.
研究的目的:
- 评估慢性病阶段G4-G5 (CKD G4/5),透析患者和移植接受者 (KTR) 中PCC的患病率和负担.
- 在这些患者群体中确定与PCC相关的风险因素.
主要方法:
- 一项前性队列研究包括接种疫苗的CKD G4/5,透析患者和KTR.
- 在接种疫苗后测量了抗体水平.
- 评估了长期症状,并使用逻辑回归来比较以前的COVID-19和没有COVID-19的患者.
主要成果:
- 在CKD G4/5中,PCC的患病率为29%,在透析患者中为21%,在KTR中为24%.
- 长期症状在患有COVID-19的患者 (24%) 和没有COVID-19的患者 (17%) 中更常见.
- 较低的疫苗接种后抗体水平和COVID-19住院治疗与PCC几率的增加有关.
结论:
- CKD G4/5,透析患者和KTR对PCC敏感,在SARS-CoV-2疫苗接种后具有显著的症状负担.
- 低抗体水平和之前的COVID-19住院治疗是这些人群中PCC的关键风险因素.
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